Oxford-AstraZeneca CoviShield COVID-19 Vaccine

 Vaxzevria, the COVID-19 vaccine developed by the University of Oxford and AstraZeneca, may cause some of the mostly mild-to-moderate side effects that people often encounter after any vaccination. However, there are also some recent controversies surrounding rare blood clotting incidents linked to this vaccine.All data and statistics are based on publicly available data at the time of publication. Some information may be out of date. Visit our coronavirus hub and follow our live updates page for the most recent information on the COVID-19 pandemic.The Oxford-AstraZeneca COVID-19 vaccine — also known as Vaxzevria, as of March 25, 2021 — is a two-dose vaccine jointly developed by the Oxford Vaccine Group and pharmaceutical company AstraZeneca to target the SARS-CoV-2 virus.Serum Institute of India’s COVID-19 vaccine, called Covishield, is a version of the Oxford-AstraZeneca vaccine that manufacturers in India produce locally.According to AstraZeneca’s primary analysis of phase 3 trial data, the vaccine has a 76% efficacy rate after both doses.

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According to the vaccine’s safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following:

headache (52.6%)

fatigue (53.1%)

muscle or joint pain (44% or 26.4%)

fever (33.6%)

chills (31.9%)

nausea (21.9%)

The percentages are based on reports from four clinical trials with a total of 23,745 participants.Individuals also commonly reported pain and irritation at the site of the vaccine injection.Additionally, an allergic reaction to certain ingredients in the vaccine may occur. Symptoms of an allergic reaction may include hives, a rash, swelling, and respiratory symptoms.There have also been a few cases of anaphylaxis, which refers to a severe and potentially life threatening allergic reaction. However, anaphylaxis is a very rare event.According to the Medicines & Healthcare products Regulatory Agency (MHRA), out of 19.5 million administered doses of Vaxzevria, only 455 (0.002%) were associated with an anaphylaxis-related adverse reaction.People who have known allergies to any of the ingredients — the active substance itself or any ingredients listed under the product information’s “List of excipients” — are advised against receiving the vaccine.All the side effects listed above are similar to those associated with other vaccines, as the Centers for Disease Control and Prevention (CDC)Trusted Source indicate for the Pfizer-BioNTech and Moderna vaccines.

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